Learn to use SMART, or Simple Modular Architecture Research Tool. SMART helps researchers visualize and understand the domains found in their proteins of interest. This handy interface will help you to understand the evolution of function within multi-domain proteins. Use SMART to bring together several domain search and analysis functions that a researcher would otherwise have to perform separately.

You will learn:

  • to perform various text and sequence searches
  • to find proteins based on their domain architecture
  • to browse for key information about the evolutionary history and relationships of domains of interest to your research


This tutorial is a part of the tutorial group Motifs and Domains. You might find the other tutorials in the group interesting:

Melina II: A Web-Based Tool for Promoter Analysis

MINT: Molecular Interaction Database

Gibbs Motif Sampler: A motif finder and analysis tool

MEME Suite Sequence Annotation Tools: MEME suite motif finding and annotating tools

MDscan: Motif Discovery scan for nucleotide and protein motifs

PROSITE: Database of protein domains, families and functional sites

MEME Suite TOMTOM and GOMO algorithms: Motif discovery tool that can detect conserved motifs in a set of DNA or protein sequences that you provide

MEME Suite GLAM2 Algorithm: Part of a motif discovery tool that can detect conserved motifs in a set of DNA or protein sequences.

MEME Algorithm: Multiple Expectation Maximum for Motif Elicitation

MEME Suite Overview: Motif-based sequence analysis tools

InterPro: A comprehensive protein signature resource


Proteins : Tools that are primarily used in the storage, retrieval, or exploration of amino acid based data. Some tools may also involve nucleotide sequence information.


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