Learn to use the PSI-Nature Structural Biology Knowledgebase (SBKB), which integrates a wide variety of structural biology and structural genomics resources into one easy to navigate site in order to turn this vast set of information into knowledge important in understanding living systems and disease. Each month the Structural Biology Update provides: editorials on research advances, a primer on a featured molecule, news articles, new additions to the SBKB research library, and a listing of events for the structural biology and structural genomics community. The SBKB connects biological information from a wide variety of popular web resources (KEGG, Reactome, NCBI, and more) with vast amounts of structural information available from the Protein Data Bank (PDB) and other Protein Structure Initiative (PSI) resources into one knowledgebase. Its simple search interface allows researchers to search by sequence, structure or text and provides well organized, easy to navigate result summaries and detailed reports of results.

You will learn:

  • To search the SBKB with a sequence or structure, and how to navigate the results
  • How to navigate search results to obtain information from various information sources
  • How text searches differ from other types of SBKB searches, and what information is available in their results
  • How you can propose biologically relevant proteins as structural targets to the Protein Structure Initiative
  • About other valuable features of the SBKB resource


This tutorial is a part of the tutorial group Protein-centric and protein structure resources. You might find the other tutorials in the group interesting:

Pfam: Protein Domain families

UniProt: UniProt, Universal Protein Resource

RCSB PDB: RCSB Protein Data Bank

MMDB: Molecular Modeling Database at NCBI

Entrez Protein: NCBI's Entrez Protein for amino acid-centric information


Proteins : Tools that are primarily used in the storage, retrieval, or exploration of amino acid based data. Some tools may also involve nucleotide sequence information.


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News Updates Related to the PDB (Protein Data Bank), etc.: This is a quick post to update you on events & news items that I've gathered that are associated with the Protein Data Bank and other protein resources. We recently received a suggestion for the RCSB P...

Tip of the Week: From UniProt to the PSI SBKB and Back Again: It is often beneficial to visit multiple biomedical databases or resources, even if they seem to provide overlappingĀ  information because no two resources focus on the exact same information, or prese...

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Tip of the Week: A year of tips III (first half of 2010): As you may know, we've been doing tips-of-the-week for three years now. We have completed around 150 little tidbit introductions to various resources*. At the end of the year we've established a sort o...


Recent BioMed Central research articles citing this resource

Liu Yichuan et al., Copy number variation in CEP57L1 predisposes to congenital absence of bilateral ACL and PCL ligaments. Human Genomics (2015) doi:10.1186/s40246-015-0053-z

DePietro J Paul et al., Quantification of the impact of PSI:Biology according to the annotations of the determined structures Computational analysis. BMC Structural Biology (2013) doi:10.1186/1472-6807-13-24

Fajardo J Eduardo et al., Protein structure based prediction of catalytic residues Structural analysis. BMC Bioinformatics (2013) doi:10.1186/1471-2105-14-63

Lee David et al., 1,000 structures and more from the MCSG. BMC Structural Biology (2011) doi:10.1186/1472-6807-11-2

Hodis Eran et al., Proteopedia - a scientific "wiki" bridging the rift between three-dimensional structure and function of biomacromolecules. Genome Biology (2008) doi:10.1186/gb-2008-9-8-r121