Database of protein domains, families and functional sites
Tutorial and training materials by OpenHelix
| Learn to use the PROSITE, a database that gathers domain, functional site and protein family information. You can scan protein sequences against the entries in the PROSITE database using ScanProsite. Use the PRATT tool to discover patterns in a group of unaligned sequences or us the MyDomains Image Creator to create custom domain graphics for displaying your data. | Advertisement:
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You'll learn:
- how to access information on domains, functional sites and protein families in PROSITE
- to perform a quick and an advanced protein sequence scan
- to find patterns in protein sequences using PRATT
- to use MyDomains to create custom domain graphics
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Recent BioMed Central research articles citing this resourceWierzbicka-Woś Anna et al., Cloning and characterization of a novel cold-active glycoside hydrolase family 1 enzyme with β-glucosidase, β-fucosidase and β-galactosidase activities Protein and enzyme technology. BMC Biotechnology (2013) doi:10.1186/1472-6750-13-22 Callahan Alison et al., Ontology-Based Querying with Bio2RDF’s Linked Open Data Proceedings of the Bio-Ontologies Special Interest Group 2012 Bio-Ontologies 2012. Journal of Biomedical Semantics (2013) doi:10.1186/2041-1480-4-S1-S1 Terova Genciana et al., PepT1 mRNA expression levels in sea bream ( Sparus aurata ) fed different plant protein sources Biomedical and Life Sciences. SpringerPlus (2013) doi:10.1186/2193-1801-2-17 Krenek Sascha et al., Convergent evolution of heat-inducibility during subfunctionalization of the Hsp70 gene family Genome evolution and evolutionary systems biology. BMC Evolutionary Biology (2013) doi:10.1186/1471-2148-13-49 Srinivasan M Satish et al., Mining for class-specific motifs in protein sequence classification Structural analysis. BMC Bioinformatics (2013) doi:10.1186/1471-2105-14-96 |
More about the resource:
The PROSITE resource is one database in a collection of protein-focused Swiss-Prot databases on the ExPASy proteomics server supported by the Swiss Institute of Bioinformatics. This database was developed in parallel with Swiss-Prot and as a result, allows users to easily navigate through the wide array of protein information found in the Swiss-Prot collection of databases. PROSITE is also complemented by a tool called ProRule, which is a collection of rules based on profiles and patterns. This adds to the discriminatory power of the profiles and patterns found in PROSITE, by providing additional information about functionally and/or structurally critical amino acids.
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