Performs multiple sequence alignments
Tutorial and training materials by OpenHelix
|Learn to use the ClustalW2 resource at the EBI Toolbox site for performing multiple sequence alignments, or MSA. MSA allow us to analyze the evolutionary relationship between species on a molecular sequence level. As well, multiple sequence alignments can help us to identify functionally important positions in a sequence family by simply looking at the conservation of positions or motifs within the sequence data.|
Download the example data file by clicking here.
- some background and theory for multiple sequence alignments
- how to conduct sequence alignments using
- to understand and adjust the results of ClustalW2 alignments
Recent BioMed Central research articles citing this resource
Jaschob Daniel et al., SnipViz: a compact and lightweight web site widget for display and dissemination of multiple versions of gene and protein sequences. BMC Research Notes (2014) doi:10.1186/1756-0500-7-468
Ahmed Fouad Salwa et al., Fecal carriage of extended-spectrum β-lactamases and AmpC-producing Escherichia coli in a Libyan community. Annals of Clinical Microbiology and Antimicrobials (2014) doi:10.1186/1476-0711-13-22
Li Caili et al., Molecular characterization of the SPL gene family in Populus trichocarpa Genomics and evolution. BMC Plant Biology (2014) doi:10.1186/1471-2229-14-131
Dixit M Sameer et al., Cholera outbreaks (2012) in three districts of Nepal reveal clonal transmission of multi-drug resistant Vibrio cholerae O1 Bacterial and fungal diseases. BMC Infectious Diseases (2014) doi:10.1186/1471-2334-14-392
Gajapathy Kanapathy et al., Molecular characterization of the malaria vector Anopheles barbirostris van der Wulp in Sri Lanka. Parasites Vectors (2014) doi:10.1186/1756-3305-7-348
More about the resource:
ClustalW2 web-based interface featured in this tutorial is provided by the European Bioinformatics Institute (EBI). The Clustal program was originally published by Thompson et al from Toby Gibsons group in 1994, and was later updated by Larkin et al. ClustalW can be downloaded as source code or as binaries for various operating systems at www.clustal.org, provided by the Conway Institute at the University College of Dublin.
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