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Performs multiple sequence alignments

Tutorial and training materials by OpenHelix

Learn to use the ClustalW2 resource at the EBI Toolbox site for performing multiple sequence alignments, or MSA. MSA allow us to analyze the evolutionary relationship between species on a molecular sequence level. As well, multiple sequence alignments can help us to identify functionally important positions in a sequence family by simply looking at the conservation of positions or motifs within the sequence data.
Download the example data file by clicking here.
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You'll learn:

  • some background and theory for multiple sequence alignments
  • how to conduct sequence alignments using
  • to understand and adjust the results of ClustalW2 alignments


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Recent BioMed Central research articles citing this resource

Sui Yi et al., Genomic, regulatory and epigenetic mechanisms underlying duplicated gene evolution in the natural allotetraploid Oryza minuta Comparative and evolutionary genomics. BMC Genomics (2014) doi:10.1186/1471-2164-15-11

Song D Simon et al., Variation in mitochondrial minichromosome composition between blood-sucking lice of the genus Haematopinus that infest horses and pigs. Parasites Vectors (2014) doi:10.1186/1756-3305-7-144

Sánchez-Sevilla F José et al., Deciphering gamma-decalactone biosynthesis in strawberry fruit using a combination of genetic mapping, RNA-Seq and eQTL analyses Plant genomics. BMC Genomics (2014) doi:10.1186/1471-2164-15-218

Teh Aun Boon et al., Structure to function prediction of hypothetical protein KPN_00953 (Ycbk) from Klebsiella pneumoniae MGH 78578 highlights possible role in cell wall metabolism Computational analysis. BMC Structural Biology (2014) doi:10.1186/1472-6807-14-7

Zhao Zifang et al., Genotyping and subtyping Cryptosporidium parvum and Giardia duodenalis carried by flies on dairy farms in Henan, China. Parasites Vectors (2014) doi:10.1186/1756-3305-7-190

More about the resource:

ClustalW2 web-based interface featured in this tutorial is provided by the European Bioinformatics Institute (EBI). The Clustal program was originally published by Thompson et al from Toby Gibsons group in 1994, and was later updated by Larkin et al. ClustalW can be downloaded as source code or as binaries for various operating systems at www.clustal.org, provided by the Conway Institute at the University College of Dublin.


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