Performs multiple sequence alignments
Tutorial and training materials by OpenHelix
|Learn to use the ClustalW2 resource at the EBI Toolbox site for performing multiple sequence alignments, or MSA. MSA allow us to analyze the evolutionary relationship between species on a molecular sequence level. As well, multiple sequence alignments can help us to identify functionally important positions in a sequence family by simply looking at the conservation of positions or motifs within the sequence data.|
Download the example data file by clicking here.
- some background and theory for multiple sequence alignments
- how to conduct sequence alignments using
- to understand and adjust the results of ClustalW2 alignments
Recent BioMed Central research articles citing this resource
Ritter Andrés et al., Transcriptomic and metabolomic analysis of copper stress acclimation in Ectocarpus siliculosus highlights signaling and tolerance mechanisms in brown algae Plant-abiotic interactions. BMC Plant Biology (2014) doi:10.1186/1471-2229-14-116
Pattemore A Julie et al., The genome sequence of the biocontrol fungus Metarhizium anisopliae and comparative genomics of Metarhizium species Comparative and evolutionary genomics. BMC Genomics (2014) doi:10.1186/1471-2164-15-660
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Liu Bobin et al., WUSCHEL-related Homeobox genes in Populus tomentosa : diversified expression patterns and a functional similarity in adventitious root formation Plant genomics. BMC Genomics (2014) doi:10.1186/1471-2164-15-296
Kaur Kohinoor et al., DevR (DosR) mimetic peptides impair transcriptional regulation and survival of Mycobacterium tuberculosis under hypoxia by inhibiting the autokinase activity of DevS sensor kinase Microbial genetics, genomics and proteomics. BMC Microbiology (2014) doi:10.1186/1471-2180-14-195
More about the resource:
ClustalW2 web-based interface featured in this tutorial is provided by the European Bioinformatics Institute (EBI). The Clustal program was originally published by Thompson et al from Toby Gibsons group in 1994, and was later updated by Larkin et al. ClustalW can be downloaded as source code or as binaries for various operating systems at www.clustal.org, provided by the Conway Institute at the University College of Dublin.
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