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Performs multiple sequence alignments

Tutorial and training materials by OpenHelix

Learn to use the ClustalW2 resource at the EBI Toolbox site for performing multiple sequence alignments, or MSA. MSA allow us to analyze the evolutionary relationship between species on a molecular sequence level. As well, multiple sequence alignments can help us to identify functionally important positions in a sequence family by simply looking at the conservation of positions or motifs within the sequence data.
Download the example data file by clicking here.
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You'll learn:

  • some background and theory for multiple sequence alignments
  • how to conduct sequence alignments using
  • to understand and adjust the results of ClustalW2 alignments


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Recent BioMed Central research articles citing this resource

Yang Zefeng et al., Adaptive evolution and divergent expression of heat stress transcription factors in grasses Genome evolution and evolutionary systems biology. BMC Evolutionary Biology (2014) doi:10.1186/1471-2148-14-147

Zaher Hussam et al., Consuming viscous prey: a novel protein-secreting delivery system in neotropical snail-eating snakes Evolutionary developmental biology and morphology. BMC Evolutionary Biology (2014) doi:10.1186/1471-2148-14-58

Liedvogel Miriam et al., No evidence for assortative mating within a willow warbler migratory divide. Frontiers in Zoology (2014) doi:10.1186/s12983-014-0052-2

Shih Ming-Che et al., BeMADS1 is a key to delivery MADSs into nucleus in reproductive tissues- De novo characterization of Bambusa edulis transcriptome and study of MADS genes in bamboo floral development Development and cell biology. BMC Plant Biology (2014) doi:10.1186/1471-2229-14-179

Dubey K Mukesh et al., Hydrophobins are required for conidial hydrophobicity and plant root colonization in the fungal biocontrol agent Clonostachys rosea Microbial genetics, genomics and proteomics. BMC Microbiology (2014) doi:10.1186/1471-2180-14-18

More about the resource:

ClustalW2 web-based interface featured in this tutorial is provided by the European Bioinformatics Institute (EBI). The Clustal program was originally published by Thompson et al from Toby Gibsons group in 1994, and was later updated by Larkin et al. ClustalW can be downloaded as source code or as binaries for various operating systems at www.clustal.org, provided by the Conway Institute at the University College of Dublin.


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